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KMID : 0882419940470030395
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Korean Journal of Medicine
1994 Volume.47 No. 3 p.395 ~ p.400
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A Case of Cushing's Syndrome due to Bilateral Adrenocortical Adnomas
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원욱희
김진안/라선영/정윤석/이현철/허갑범/박정수/성순희
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Abstract
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ACTH-independent Cushing's syndrome is caused by autonomous production of cortisol, usually by an adrenal adenoma, carcinoma, or primary adrenocortical micronodular dysplasia. Cushing's syndrome due to adrenocortical adenoma usually has a
unilateral
lesion and contralateral site becomes atrophic. We report a rare case of Cushing's syndrome caused by ACTH independent bilateral adrenocortical adenomas. A 48=year-old woman presented with Cushingoid features, diabetes mellitus and hypertension.
Urinary
free cortisol and 17-hydroxycorticosteroid excretion were 365.4ug/day and 16.2mg/day, respectively. Both were not suppressed after administration of high-dose dexamethsone. Plasma ACTH was 3.5pg/ml. Abdominal C-T revealed well defined bilateral
adrenal
tumors 4.0cm in diameter on the ventral side of the fight renal upper pole and 2.0 cm in diameter on the ventral side of left renal upper pole. Bilateral partial adrenalectomy was performed. The both adrenal glands showed all the pathologic
features of
adenoma.
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KEYWORD
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